Blar i forfatter "McCutcheon, James Edgar"

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    • Age-dependent effects of protein restriction on dopamine release 

      Naneix, Fabien; Peters, Kate Z.; Young, Andrew J.; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-31)
      Despite the essential role of protein intake for health and development, very little is known about the impact of protein restriction on neurobiological functions, especially at different stages of the lifespan. The dopamine system is a central actor in the integration of food-related processes and is influenced by physiological state and food-related signals. Moreover, it is highly sensitive to ...

    • Distracting stimuli evoke ventral tegmental area responses in rats during ongoing saccharin consumption 

      Peters, Kate Z.; Young, Andrew M J; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-11)
      Disruptions in attention, salience and increased distractibility are implicated in multiple psychiatric conditions. The ventral tegmental area (VTA) is a potential site for converging information about external stimuli and internal states to be integrated and guide adaptive behaviours. Given the dual role of dopamine signals in both driving ongoing behaviours (e.g., feeding) and monitoring salient ...

    • Introduction to the special issue: Homeostatic vs. Hedonic feeding. 

      McCutcheon, James Edgar; Williams, Diana (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)

    • Investigating the effect of physiological need states on palatability and motivation using microstructural analysis of licking 

      Naneix, Fabien; Peters, Kate; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-01)
      The study of consummatory responses during food intake represents a unique opportunity to investigate the physiological, psychological and neurobiological processes that control ingestive behavior. Recording the occurrence and temporal organization of individual licks across consumption, also called lickometry, yields a rich data set that can be analyzed to dissect consummatory responses into different ...

    • Predictive and motivational factors influencing anticipatory contrast: A comparison of contextual and gustatory predictors in food restricted and free-fed rats 

      Hayes, Jessica; Garau, Celia; Chiacchierini, Giulia; Urcelay, Gonzalo P.; McCutcheon, James Edgar; Apergis-Schoute, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
      In anticipation of palatable food, rats can learn to restrict consumption of a less rewarding food type resulting in an increased consumption of the preferred food when it is made available. This construct is known as anticipatory negative contrast (ANC) and can help elucidate the processes that underlie binge-like behavior as well as self-control in rodent motivation models. In the current investigation ...

    • Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity 

      Chiacchierini, Giulia; Naneix, Fabien; Peters, Kate Z; Aspergis-Schoute, John; Snoeren, Eelke; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Control of protein intake is essential for numerous biological processes as several amino acids cannot be synthesized de novo, however, its neurobiological substrates are still poorly understood. In the present study, we combined in vivo fiber photometry with nutrient-conditioned flavor in a rat model of protein appetite to record neuronal activity in the VTA, a central brain region for the control ...

    • Protein preference and elevated plasma FGF21 induced by dietary protein restriction is similar in both male and female mice 

      Volcko, Karin Linnea; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-19)
      Animals that are moderately protein restricted respond to this dietary stress by increasing consumption of protein-containing foods. This is true in many species, including rodents. Rodent models of protein restriction have typically relied on only male subjects, and there are plausible reasons why female rodents may respond differently to dietary protein restriction. To address this gap in ...

    • Restriction of dietary protein in rats increases progressive-ratio motivation for protein 

      Chiacchierini, Giulia; Naneix, Fabien; Apergis-Schoute, John; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-29)
      Low-protein diets can impact food intake and appetite, but it is not known if motivation for food is changed. In the present study, we used an operant behavioral task – the progressive ratio test – to assess whether motivation for different foods was affected when rats were maintained on a protein-restricted diet (REST, 5% protein diet) compared to non-restricted control rats (CON, 18% protein). ...